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Information on Celexa

Pronounced:sell-EX-ah
Generic name:Citalopram hydrobromide

Why is Celexa prescribed?

Celexa is used to treat major depression--a stubbornly low mood that persists nearly every day for at least 2 weeks and interferes with everyday living. Symptoms may include loss of interest in your usual activities, insomnia or excessive sleeping, a change in weight or appetite, constant fidgeting or a slowdown in movement, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and repeated thoughts of suicide.

Like the antidepressant medications Paxil, Prozac, and Zoloft, Celexa is thought to work by boosting serotonin levels in the brain. Serotonin, one of the nervous system's primary chemical messengers, is known to elevate mood.

Most important fact about Celexa

Be careful to avoid taking Celexa for 2 weeks before or after using an antidepressant known as an MAO inhibitor. Drugs in this category include Marplan, Nardil, and Parnate. Combining Celexa with one of these medications could lead to a serious--even fatal--reaction.

How should you take Celexa?

Take Celexa once a day, in the morning or evening, with or without food. Although your depression will begin to lift in 1 to 4 weeks, you should continue taking Celexa regularly. It takes several months for the medication to yield its full benefits.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.

--Storage instructions...

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Celexa.

More common side effects may include:

abdominal pain
agitation
anxiety
diarrhea
drowsiness
dry mouth
ejaculation disorders
fatigue
impotence
indigestion
insomnia
loss of appetite
nausea
painful menstruation
respiratory tract infection
sinus or nasal inflammation
sweating
tremor
vomiting

Less common side effects may include:

amnesia
attempted suicide
confusion
coughing
decreased sexual drive
depression
excessive urination
fever
gas
impaired concentration
increased appetite
increased salivation
itching
joint pain
lack of emotion
loss of menstruation
low blood pressure
migraine
muscle pain
rapid heartbeat
rash
skin tingling
taste disturbances
visual disturbances
weight gain
weight loss
yawning

Rare side effects may include:

abnormal dreams
acne
aggressive behavior
alcohol intolerance
angina (chest pain)
arthritis
belching
bone pain
breast enlargement
breast pain
bronchitis
bruising
chills
conjunctivitis (pinkeye)
decreased muscle movements
delusions
dermatitis
difficulty breathing
difficulty swallowing
dizziness
drug dependence
dry eyes
dry skin
eczema
emotional instability
excessive milk flow
excessive muscle tone
eye pain
fainting
feeling of well-being
flu-like symptoms
flushing
frequent urination
gum inflammation
hair loss
hallucinations
heart attack
heart failure
hemorrhoids
high blood pressure
hives
hot flashes
inability to hold urine
inability to urinate completely
increased sex drive
increased urination
involuntary muscle movements
leg cramps
mouth sores
muscle weakness
nosebleeds
numbness
painful erection
painful urination
panic
paranoia
pneumonia
psoriasis
psychosis
ringing in the ears
sensitivity to light
skin discoloration
slow heartbeat
stomach and intestinal inflammation
stroke
swelling
teeth grinding
thirst
uncontrollable muscle movements
unsteady or abnormal walk
vaginal bleeding

Why should this drug not be prescribed?

If Celexa gives you an allergic reaction, you cannot continue using it. Also remember that Celexa must never be combined with an MAO inhibitor (see "Most important fact about Celexa drug," above).

Special warnings about this medication

In recommended doses, Celexa does not seem to impair judgment or motor skills. However, a theoretical possibility of such problems remains, so you should use caution when driving or operating dangerous equipment until you are certain of Celexa's effect.

There is a slight chance that Celexa will trigger a manic episode. Use Celexa with caution if you suffer from manic-depression (bipolar disorder). Use caution, too, if you are over 60 years old, have liver or kidney problems, suffer from heart disease or high blood pressure, or have ever had seizures.

Possible food and drug interactions when taking this medication

Celexa does not increase the effects of alcohol. Nevertheless, it's considered unwise to combine Celexa with alcohol or any other drug that affects the brain. (Be particularly careful to avoid MAO inhibitors.)

If Celexa is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Tell your doctor about any prescription or over-the-counter drugs you are planning to take, and be especially certain to tell the doctor before combining Celexa with the following:

Carbamazepine (Tegretol)
Cimetidine (Tagamet)
Erythromycin (Eryc, Ery-Tab)
Fluconazole (Diflucan)
Itraconazole (Sporanox)
Ketoconazole (Nizoral)
Lithium (Lithobid, Lithonate)
Metoprolol (Lopressor)
Omeprazole (Prilosec)
Other antidepressants such as Elavil, Norpramin, Pamelor, and Tofranil
Sumatriptan (Imitrex)
Warfarin (Coumadin)

Special information if you are pregnant or breastfeeding

The effects of Celexa during pregnancy have not been adequately studied, and the potential for harm has not been ruled out. If you are pregnant or plan to become pregnant while on Celexa therapy, tell your doctor immediately.

Celexa appears in breast milk and will affect the nursing infant. You should consider discontinuing either breastfeeding or Celexa. Talk with your doctor about the pros and cons of each option.

Recommended dosage

ADULTS
The recommended starting dose is 20 milligrams once a day. Dosage is usually increased to 40 milligrams once daily after at least a week has passed. Do not exceed 40 milligrams a day.

For older adults and those who have liver problems, the recommended dose is 20 milligrams once a day.